Approaching ‘ kit - type ’ labelling with 68 Ga : The the DATA chelators

The DATA chelators, are a novel class of tri-anionic chelators ligands based on the 6-amino1,4-diazepine-triacetic acid, core structure, that have been introduced recently for the chelation of Ga. Compared to established macrocyclic chelators based on the cyclen scaffold (i.e. DOTA-, DO3Aand DO2Aderivatives), they enable undergo quantitative radiolabelling both more rapidly and under considerably milder conditions. To date, a detailed examination of the radiochemical characteristics of these chelators had not been carried out. In this study, we present a systematic evaluation of the labelling of four DATA chelators – DATA, DATA, DATA and DATA. – by Ga is presented The results of this study underlinehighlight the extraordinary potential of this novel new class of chelators for application in molecular imaging using Ga-PETpositron emission tomography (PET).